Rheumatology & Autoimmune

6+ hour, 17+ min ago   (681+ words) A Chinese case series of eleven children with lupus identifies headache, transverse sinus involvement, elevated CRP and thrombocytopenia as the hallmark features of cerebral venous sinus thrombosis, with early combined treatment yielding favorable outcomes. Among the many complications that systemic…...

10+ hour, 22+ min ago   (75+ words) New research in mice shows that curli amyloid fibers from Salmonella and E. coli biofilms can drive the production of anti-C1q and anti-dsDNA autoantibodies, linking infection and dysbiosis to lupus kidney disease. Subject of Research: The induction of anti-C1q and anti-dsDNA…...

1+ week, 4+ day ago   (758+ words) Every patient evaluated in a small early-stage lupus trial has stopped taking immunosuppressant drugs after a single infusion of an experimental donor-derived cell therapy, Adicet Bio reported on Sept. 28. More than half of the patients followed for a full year…...

1+ day, 23+ hour ago   (103+ words) Victoria Werth, MD, of the University of Pennsylvania, discusses phase 2 findings showing that daxdilimab, an anti-ILT7 antibody that depletes plasmacytoid dendritic cells, improved skin activity in patients with discoid lupus at 2 doses vs placebo. She notes that improvement emerged by…...

2+ day, 8+ hour ago   (166+ words) Instead, older age at diagnosis was linked to a lower likelihood of receiving advanced therapy (HR per standard deviation, 0.74; 95% CI, 0.55-1.00). Additional exploratory analyses demonstrated that patients aged 62 years and older were significantly less likely to initiate treatment with a bDMARD…...

2+ day, 11+ hour ago   (492+ words) Both doses of the anti-ILT7 antibody daxdilimab reduced CLASI-A scores vs placebo at week 24 in moderate-to-severe, treatment-refractory discoid lupus. Daxdilimab, an anti-ILT7 antibody depleting plasmacytoid dendritic cells (pDCs), reduced disease activity vs placebo in moderate to severe discoid lupus erythematosus…...

2+ day, 13+ hour ago   (262+ words) AMONG PATIENTS with ankylosing spondylitis (AS), a validated five-protein plasma signature has been linked to high structural damage, researchers have found, suggesting that plasma protein signatures could complement imaging by capturing biological processes beyond systemic inflammation. Pathological bone formation in…...

6+ day, 23+ hour ago   (534+ words) Joint pain is common. It is so common that most people who develop it, particularly in mid-life and beyond, attribute it to wear and tear, overuse, or the general physical demands of getting older. In many cases, this attribution is…...

3+ day, 19+ hour ago   (182+ words) Biogen has announced 52-week results from the phase 2 part of the ongoing AMETHYST phase 2/3 study (Part A) of litifilimab in people living with cutaneous lupus erythematosus (CLE). The updated results, presented at the European Academy of Dermatology and Venereology (EADV) 2026 Congress…...

3+ day, 15+ hour ago   (52+ words) Lakefront Biotherapeutics has a meaningful opportunity with its asset gamgertamig for the treatment of rare autoimmune diseases, RBC Capital Markets said in a note Wednesday. Gamgertamig has... Biotechnology & Medical Research Lakefront Biotherapeutics' Gamgertamig Has Meaningful Opportunity in Rare Autoimmune Diseases,…...